Neutron | Needlefree Catheter Patency Device

The Neutron Catheter Patency Device Reduces Reflux to Help You

Minimize Occlusions

Maintaining catheter patency and minimizing occlusions can be important steps in your efforts to enhance patient safety, improve patient outcomes, and reduce costs.

But despite your efforts, central line occlusions, which are frequently caused by blood reflux,1 remain a significant issue that can result in delays in critical patient care, increased risk of infection, and increased healthcare costs. That’s why reducing the risk of catheter occlusions may help you decrease the need for expensive declotting agents such as t-PA, and reduce the clinical costs associated with managing catheter occlusions.

Neutron’s breakthrough anti-reflux technology helps you stop occlusions before they start, while providing a safe and effective microbial barrier.

Unlike other technologies, such as positive displacement needlefree connectors, Neutron is the only device FDA-cleared to prevent all forms of reflux into a catheter and utilize ICU Medical’s patented needlefree connector technology
which has been proven to minimize contamination and help you lower the risk of catheter related bloodstream
infections (CRBSI)2,3,4

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Avoid Delays in
Critical Patient Care

Neutron may help avoid delays in therapy of critical intravenous medications  (e.g., antibiotics and oncolytics), nutritional support, and blood products.

Avoid Patient
Discomfort and Pain

Neutron may help avoid patient discomfort and pain caused by unnecessary needlesticks, catheter restarts, and manipulating the IV site.

Unnecessary Costs

Neutron may help minimize
unnecessary costs that add up
when treating an occlusion.

Help Reduce Risk
of Infection

Neutron may help reduce the risk of infection by preventing thrombosis and minimizing IV line manipulation.

Designed to Prevent All Known Causes of Reflux into a Catheter

Reflux of blood into the catheter has been shown to contribute to biofilm formation and catheter occlusion.

Internal Causes

  • Patient Vascular Pressure Changes Caused by:
    Coughing   Movement
    Sneezing   Crying

External Causes

  • Connection and Disconnection of a Luer
  • IV Bag Running Dry or an Infusion Pump Stopping
  • Syringe Plunger Rebound

How it works

Superior Anti-Reflux Technology

Because of an innovative design that incorporates a patented bi-directional silicone valve and bellows feature to help prevent reflux at all times, Neutron helps maintain catheter patency during times when traditional connectors have been shown to occlude most often.

Valve During Aspiration

Valve During Infusion

Valve With No Fluid Flow

Valve During Reflux Challenge

Unlike other anti-reflux valves, Neutron’s patented technology provides the unique ability to absorb and physically compensate for pressure variations that typically result in blood reflux into a catheter.


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Customize Neutron

Add a Splash of Color for Quick and Easy Line Identification.

Customize Neutron with a variety of color-coded rings to help you improve IV line management and avoid medication mix-ups.

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Technical Specs

Residual Volume: 0.1 mL
Flow Rate at Gravity: 100 mL / minute
Blood Compatibility: Yes
MRI Compatibility: Yes
High Pressure Compatibility: 10 mL / second


Alcohol: Yes
Lipids: Yes
Chlorhexidine: Yes
Chemotherapy: Yes

Neutron's saline flush option allows you to reduce risks, cost, and time associated with Heparin use.



  1. Gorski, Lisa A MS, RN, CS, CRNI. Central Venous Access Device Occlusions: Part 1: Thrombotic Causes and Treatment. Home Healthcare Nurse. 21:2 115-121, February 2003.

  2. Ryder M, James G, Pulchini E, Bickle L, Parker A. Differences in bacterial transfer and fluid path colonization through needlefree connector-catheter systems in vitro. Presented at the Infusion Nursing Society Meeting, May 2011.

  3. Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) at an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028.

  4. Evaluation of the Clave® technology and resistance to microbial ingress. Report of a study commissioned by ICU and conducted by Nelson Laboratories, 2008. M1-1212 rev. 03.

  5. ICU Medical Study Summary. Observational In-Vivo Evaluation of the Neutron™ Needlefree Catheter Patency Device and its Effects on Catheter Occlusions in a Home Care Setting, 2011.

  6. Yebenes J, Delgado M, Sauca G, Serra-Prat M, Solsona M, Almirall J, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561.

  7. JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.; 36:181-189.

  8. Ryder M, RN, PhD. Bacterial transfer through needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007.

  9. Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010.

  10. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.

White Papers

Clinical Reports

Educational Seminars & Presentations

Needle Free Connectors

Needle-free Connectors: Split Septum vs. Mechanical Valve…Can this classification model predict infection risk? By Marcia Ryder, PhD MS RN. APIC 2010 Satellite Symposium, Tuesday, July 13th, 2010. Running time: 1hr. 27min.
Click Here to View the Seminar >


Product Reference


Disinfect to Protect

  • When placing a new Neutron on a catheter, disinfect the catheter hub and prime the Neutron.
  • Before accessing a Neutron, always disinfect the injection site with the approved antiseptic per facility protocol.
  • Scrub the injection site in accordance with facility protocol for appropriate scrubbing and dry times.

Disinfect to Protect

Administer or Aspirate

  • Attach IV tubing, syringe or blood tube holder to Neutron by inserting the luer and twisting ¼ turn, or until a friction fit is achieved.
  • When aspirating blood using evacuated tubes, the blood tube will fill slightly slower because of the Neutron anti-reflux valve.
  • To disconnect, grasp Neutron and then twist the mating luer away from Neutron until loose. Do not hold catheter hub during disconnect as this may cause accidental removal of Neutron from hub.

Administer or Aspirate

Flush After Each Use

  • Always flush Neutron with normal saline or in accordance with facility protocol after each use.
  • Use routine flushing in accordance with facility protocol in order to maintain catheter patency.
  • Change Neutron in accordance with facility protocol and CDC guidelines.

Flush After Each Use

Technical Videos

Neutron In-Service Video

Your guide to the safe and effective use of Neutron.

Use Case Recommendations