NanoClave | Low Profile Neutral Displacement Connector

Helping Keep Your Tiniest Patients

Safe From Infection

While Effectively Managing Their Fluids

Preventing infections and managing patient fluids are critical elements of neonatal infusion therapy. And NanoClave is here to help.

Neonates face an increased risk for both dehydration and fluid overload. Inadequate water intake can cause the baby to become dehydrated, while excessive water intake can cause heart and lung problems or intestinal damage.2 As a result, neonatal fluid and electrolyte requirements must be carefully calculated and monitored, including the volume of flush solution infused after blood draws or administration.

NanoClave may help you better manage patient fluids by reducing the flush volume required to clear the IV connector of blood components.

NanoClave is specifically designed to help keep your neonatal and pediatric patients safe by minimizing flush volumes
and providing a safe and effective microbial barrier.1 Because of its light weight, small size and smooth profile,
NanoClave may also help you minimize irritation and discomfort.

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Minimize Flush Volumes

Minimal residual volume of only
0.02 mL allows for lower flush volumes which may help your efforts to maintain appropriate patient fluid balance.

Reduce the Risk of Bloodstream Infection

A mechanically and microbiologically closed system provides a safe and effective microbial barrier to help minimize infection risks.

Minimize Patient Discomfort

The small size and weight of the NanoClave make it the perfect solution for your neonatal and pediatric patients.

Visualize Connector Flushing

The clear housing of the NanoClave allows for visualization of the internal fluid path upon flushing the connector.

How it works

Market-leading Infection Control Technology Proven
to Minimize Bacterial Contamination3,4,5,6,7,8

NanoClave can help your efforts to reduce infection risks by minimizing entry points for bacteria
and maximizing the effectiveness of every flush.


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Customize MicroClave

Design Patient-Ready Sets Exactly How You Need Them.

Make the most of our clinically preferred needlefree technology with made-to-order custom IV sets with no long-term contracts or minimum order requirements.

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Technical Specs

Residual Volume: 0.02 mL
Flow Rate at Gravity: 145 mL / minute
Blood Compatibility: Yes
MRI Compatibility: Yes
High Pressure Compatibility: 10 mL / second


Alcohol: Yes
Lipids: Yes
Chlorhexidine: Yes
Chemotherapy: Yes

NanoClave's saline flush option allows you to reduce risks, cost, and time associated with Heparin use.



  1. Breznock E M, DVM, PhD, Diplomate ACVS, Sylvia C J, DVM, MS., BioSurg, Inc. The in vivo evaluation of the flushing efficiency of different designs of clear needlefree connectors, March 2011.

  2. Bell EF, Acarregui MJ. Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane
    Database Syst Rev 2000;(2):CD000503.

  3. Ryder M, James G, Pulchini E, Bickle L, Parker A. Differences in bacterial transfer and fluid path colonization through
    needlefree connector-catheter systems in vitro. Presented at the Infusion Nursing Society Meeting, May 2011.

  4. Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device
    (LAD) at an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and
    Epidemiology (APIC) Conference 2010, Abstract 4-028.

  5. Evaluation of the Clave® technology and resistance to microbial ingress. Report of a study commissioned by ICU and conducted by Nelson Laboratories, 2008. M1-1212 rev. 03.

  6. J. Yebenes, M. Delgado, G. Sauca, M. Serra-Prat, M. Solsona, J. Almirall, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561.

  7. JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.;

  8. Ryder M, RN, PhD. Bacterial transfer through needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007.

  9. Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010.

  10. Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.

Product Reference


Disinfect to Protect

  • When placing a new NanoClave on a catheter, disinfect the catheter hub and prime the NanoClave.
  • Before accessing a NanoClave, always disinfect the injection site with the approved antiseptic per facility protocol.
  • Scrub the injection site in accordance with facility protocol for appropriate scrubbing and dry times.

Disinfect to Protect

Adminster or Aspirate

  • Attach IV tubing, syringe or blood tube holder to NanoClave by inserting the luer and twisting ¼ turn, or until a friction fit is achieved.
  • Do not over-tighten a luer beyond the friction fit as this may damage both the luer and the NanoClave.
  • To disconnect, grasp NanoClave and then twist the mating luer away from NanoClave until loose. Do not hold catheter hub during disconnect as this may cause accidental removal of NanoClave from hub.

Adminster or Aspirate

Flush After Each Use

  • Flush the NanoClave with normal saline or in accordance with facility protocol. After blood use, the NanoClave can be flushed clean and does not require change-out.
  • Use routine flushing in accordance with facility protocol in order to maintain catheter patency.
  • Change NanoClave in accordance with facility protocol and CDC guidelines.

Flush After Each Use

Use Case Recommendations